PARP1-DEPENDENT RECRUITMENT OF THE FBXL10-RNF68-RNF2 UBIQUITIN LIGASE TO SITES OF DNA DAMAGE CONTROLS H2A.Z LOADING

PARP1-dependent recruitment of the FBXL10-RNF68-RNF2 ubiquitin ligase to sites of DNA damage controls H2A.Z loading

The mammalian FBXL10-RNF68-RNF2 ubiquitin ligase complex (FRRUC) mono-ubiquitylates H2A at Lys119 to repress transcription in unstressed cells.We found that the FRRUC is rapidly and transiently recruited to sites of DNA damage in a PARP1- and TIMELESS-dependent manner to promote mono-ubiquitylation of H2A at Lys119, a local decrease of H2A Snaffle

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Mechanical properties and biocompatibility of a novel miniscrew made of Zr70Ni16Cu6Al8 bulk metallic glass for orthodontic anchorage

Abstract The purpose of the present study was to fabricate a miniscrew possible for clinical application using Zr70Ni16Cu6Al8 bulk metallic glass (BMG), which has high mechanical strength, low elastic modulus, and high biocompatibility.First, the elastic moduli of Zr-based metallic glass rods made of Zr55Ni5Cu30Al10, Zr60Ni10Cu20Al10, Zr65Ni10Cu17.

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